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The evolution of H5N1 influenza viruses in ducks in southern China
Chen, H(); Deng, G(); Li, Z(); Tian, G(); Li, Y(); Jiao, P(); Zhang, L(); Liu, Z(); Webster, RG(); Yu, K()
2004
发表期刊PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
卷号101期号:28页码:10452-10457
摘要The pathogenicity of avian H5N1 influenza viruses to mammals has been evolving since the mid-1980s. Here, we demonstrate that H5N1 influenza viruses, isolated from apparently healthy domestic ducks in mainland China from 1999 through 2002, were becoming progressively more pathogenic for mammals, and we present a hypothesis explaining the mechanism of this evolutionary direction. Twenty-one viruses isolated from apparently healthy ducks in southern China from 1999 through 2002 were confirmed to be H5N1 subtype influenza A viruses. These isolates are antigenically similar to A/Goose/Guangdong/l/96 (H5N1) virus, which was the source of the 1997 Hong Kong "bird flu" hemagglutinin gene, and all are highly pathogenic in chickens. The viruses form four pathotypes on the basis of their replication and lethality in mice. There is a clear temporal pattern in the progressively increasing pathogenicity of these isolates in the mammalian model. Five of six H5N1 isolates tested replicated in inoculated ducks and were shed from trachea or cloaca, but none caused disease signs or death. Phylogenetic analysis of the full genome indicated that most of the viruses are reassortants containing the A/Goose/Guangdong/l/ 96-like hernagglutinin gene and the other genes from unknown Eurasian avian influenza viruses. This study is a characterization of the H5N1 avian influenza viruses recently circulating in ducks in mainland China. Our findings suggest that immediate action is needed to prevent the transmission of highly pathogenic avian influenza viruses from the apparently healthy ducks into chickens or mammalian hosts.
学科领域Multidisciplinary Sciences
DOI10.1073/pnas.0403212101
收录类别SCI
语种英语
WOS记录号WOS:000222664200038
出版者NATL ACAD SCIENCES
nyguid7a7d0818-3365-4c81-a63e-67b4d518aaeb
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被引频次:366[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.nais.net.cn/handle/2HMLN22E/230463
专题哈尔滨兽医研究所
通讯作者Chen, H()
作者单位(1)Chinese Acad Agr Sci, Harbin Vet Res Inst, Natl Key Lab Vet Biotechnol, Harbin 150001, Peoples R China;(2)Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin 150001, Peoples R China;(3)St Jude Childrens Res Hosp, Div Virol, Dept Infect Dis, Memphis, TN 38105 USA
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Chen, H,Deng, G,Li, Z,et al. The evolution of H5N1 influenza viruses in ducks in southern China[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2004,101(28):10452-10457.
APA Chen, H.,Deng, G.,Li, Z.,Tian, G.,Li, Y.,...&Yu, K.(2004).The evolution of H5N1 influenza viruses in ducks in southern China.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,101(28),10452-10457.
MLA Chen, H,et al."The evolution of H5N1 influenza viruses in ducks in southern China".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101.28(2004):10452-10457.
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