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A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones
Ren, Qingyun1; Shi, YanXia2; Gu, Yucheng1,3; Li, Baoju2; He, Hongwu1
2014
发表期刊JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN0022-152X
卷号51期号:2页码:285-290
摘要Fifteen novel 2-alkylamino-3-aryl-8-cyano-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidin-4(3H)-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j, 6k, 6l, 6m, 6n, 6o were designed and have been successfully synthesized via tandem aza-Wittig and annulation reactions with the corresponding iminophosphorances 4, aryl isocyanate, and amines in good yields. Their structures were clearly verified by IR, H-1 NMR, EI-MS spectroscopy and elemental analysis, and in the case of compound 6i, analyzed by single-crystal X-ray diffraction further. The preliminary results of an in vivo bioassay showed that some compounds display moderate antifungal activity.
学科领域Chemistry, Organic ; Chemistry, Organic
DOI10.1002/jhet.1553
收录类别SCI
语种英语
WOS记录号WOS:000333382000001
出版者WILEY-BLACKWELL
nyguid4e413e16-9508-460b-a2a3-0f06e9aed09f
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.nais.net.cn/handle/2HMLN22E/148848
专题蔬菜花卉研究所_植物保护研究室
通讯作者Ren, Qingyun
作者单位1.Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China;
2.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China;
3.Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
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Ren, Qingyun,Shi, YanXia,Gu, Yucheng,et al. A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2014,51(2):285-290.
APA Ren, Qingyun,Shi, YanXia,Gu, Yucheng,Li, Baoju,&He, Hongwu.(2014).A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones.JOURNAL OF HETEROCYCLIC CHEMISTRY,51(2),285-290.
MLA Ren, Qingyun,et al."A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones".JOURNAL OF HETEROCYCLIC CHEMISTRY 51.2(2014):285-290.
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